An integrated approach to monitoring disease activity in inflammatory idiopathic myopathies

Elenco Abstract

Luca Bosco

An integrated approach to monitoring disease activity in inflammatory idiopathic myopathies

Autori

LUCA BOSCO (IINSTITUTE OF EXPERIMENTAL NEUROLOGY (INSPE), DIVISION OF NEUROSCIENCE, IRCCS SAN RAFFAELE SCIENTIFIC INSTITUTE, MILAN, ITALY – NEUROLOGIA)
ADELE RATTI (INSTITUTE OF EXPERIMENTAL NEUROLOGY (INSPE), DIVISION OF NEUROSCIENCE, IRCCS SAN RAFFAELE SCIENTIFIC INSTITUTE, MILAN, ITALY – NEUROLOGIA)
CHRISTIAN LAURINI (INSTITUTE OF EXPERIMENTAL NEUROLOGY (INSPE), DIVISION OF NEUROSCIENCE, IRCCS SAN RAFFAELE SCIENTIFIC INSTITUTE, MILAN, ITALY – NEUROLOGIA)
BENEDETTA SORRENTI (INSTITUTE OF EXPERIMENTAL NEUROLOGY (INSPE), DIVISION OF NEUROSCIENCE, IRCCS SAN RAFFAELE SCIENTIFIC INSTITUTE, MILAN, ITALY – NEUROLOGIA)
CAMILLA MIRELLA MARIA STRANO (INSTITUTE OF EXPERIMENTAL NEUROLOGY (INSPE), DIVISION OF NEUROSCIENCE, IRCCS SAN RAFFAELE SCIENTIFIC INSTITUTE, MILAN, ITALY – NEUROLOGIA)
VALENTINA CANTI (UNIT OF INTERNAL MEDICINE & DIVISION OF IMMUNOLOGY, TRANSPLANTATION AND INFECTIOUS DISEASES, IRCCS OSPEDALE SAN RAFFAELE, MILAN, ITALY – IMMUNOLOGIA)
PATRIZIA ROVERE QUERINI (UNIT OF INTERNAL MEDICINE & DIVISION OF IMMUNOLOGY, TRANSPLANTATION AND INFECTIOUS DISEASES, IRCCS OSPEDALE SAN RAFFAELE, MILAN, ITALY – IMMUNOLOGIA)
ANTONIO LAULETTA (NEUROMUSCULAR DISEASE CENTRE, DEPARTMENT OF NEUROSCIENCES, MENTAL HEALTH AND SENSORY ORGANS (NESMOS), SAPIENZA UNIVERSITY OF ROME, SANT’ANDREA HOSPITAL, VIA DI GROTTAROSSA, 1035-1039, 00189, ROME, ITALY – NEUROLOGIA)
MATTEO GARIBALDI (NEUROMUSCULAR DISEASE CENTRE, DEPARTMENT OF NEUROSCIENCES, MENTAL HEALTH AND SENSORY ORGANS (NESMOS), SAPIENZA UNIVERSITY OF ROME, SANT’ANDREA HOSPITAL, VIA DI GROTTAROSSA, 1035-1039, 00189, ROME, ITALY – NEUROLOGIA)
ALEX VICINO (NEUROLOGY IV UNIT, NEUROIMMUNOLOGY AND NEUROMUSCULAR DISEASES, FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA, MILAN, ITALY – NEUROLOGIA)
LORENZO MAGGI (NEUROLOGY IV UNIT, NEUROIMMUNOLOGY AND NEUROMUSCULAR DISEASES, FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA, MILAN, ITALY – NEUROLOGIA)
VINCENZO CARLOMAGNO (FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS, ROME, ITALY – NEUROLOGIA)
MATTEO LUCCHINI (FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS, ROME, ITALY – NEUROLOGIA)
MASSIMILIANO MIRABELLA (FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS, ROME, ITALY – NEUROLOGIA)
MASSIMO FILIPPI (INSTITUTE OF EXPERIMENTAL NEUROLOGY (INSPE), DIVISION OF NEUROSCIENCE, IRCCS SAN RAFFAELE SCIENTIFIC INSTITUTE, MILAN, ITALY – NEUROLOGIA)
UBALDO DEL CARRO (NEUROPHYSIOLOGY UNIT, NEUROLOGY DEPARTMENT, IRCCS OSPEDALE SAN RAFFAELE, MILAN, ITALY – NEUROLOGIA)
STEFANO CARLO PREVITALI (INSTITUTE OF EXPERIMENTAL NEUROLOGY (INSPE), DIVISION OF NEUROSCIENCE, IRCCS SAN RAFFAELE SCIENTIFIC INSTITUTE, MILAN, ITALY – NEUROLOGIA)

Presentatore

LUCA BOSCO

Modalità

Poster Session

Abstract

“Background & Aim
Idiopathic inflammatory myopathies (IIM) are a group of rare autoimmune conditions affecting the skeletal muscle. Decisions regarding the escalation and de-escalation of immunosuppressive therapy depend on appropriate evaluation of disease activity. Available clinical tools to monitor IIM activity are largely unsatisfactory. This multicenter retrospective longitudinal study aims to characterize IIM disease courses through the integration of routinely used instrumental techniques.
Methods
A longitudinal MS Access database was created (IIMv2.6). Retrospective data was systematically revised to assure the quality and confidentiality of all information retrieved. EMG and MRI parameters were longitudinally confronted with various clinical and biochemical myositis disease metrics. A logistic regression model was used to identify potential predictors of therapy response.
Results
One-hundred-thirty (n = 130) adult IIM patients met the inclusion criteria (immune-mediated-necrotizing-myopathy = 32, polymyositis = 31, dermatomyositis = 41, inclusion-body-myositis = 18, anti-synthetase-syndrome = 8). At baseline EMG remodeling and muscle edema at the MRI presented negative correlations with muscle strength (rs = -.56 and rs = -.42), while muscle edema best correlated with measures of multisystem disease activity (rs = .48). In the longitudinal setting, instrumental metrics presented a trend toward coherently tracking immunotherapy response.
Conclusions
We suggest that the combined use of different instrumental examinations can offer more information on IIM muscle structural and functional changes. A retrospective analysis can provide limited insight into the potentialities of these assessments for the follow-up of these patients, but it suggests how we can best use these tools to make our approach more tailored to this scope.”