GAIT PARAMETERS / COGNITIVE FUNCTION CORRELATION IN A COHORT OF PATIENTS WITH MYOTONIC DYSTROPHY TYPE 1: A SINGLE-CENTER SENSOR-BASED GAIT ANALYSIS

Elenco Abstract

BARBARA RISI

GAIT PARAMETERS / COGNITIVE FUNCTION CORRELATION IN A COHORT OF PATIENTS WITH MYOTONIC DYSTROPHY TYPE 1: A SINGLE-CENTER SENSOR-BASED GAIT ANALYSIS

Autori

BARBARA RISI (NEMO-BRESCIA CLINICAL CENTER FOR NEUROMUSCULAR DISEASES, BRESCIA, ITALY – NEUROLOGY)
ANDREA PILOTTO (DEPARTMENT OF CLINICAL AND EXPERIMENTAL SCIENCES, UNIVERSITY OF BRESCIA; DEPARTMENT OF CONTINUITY OF CARE AND FRAILTY, NEUROLOGY UNIT, ASST SPEDALI CIVILI OF BRESCIA; LABORATORY OF DIGITAL NEUROLOGY AND BIOSENSORS, UNIVERSITY OF BRESCIA, ITALY – NEUROLOGY)
ANDREA RIZZARDI (DEPARTMENT OF CLINICAL AND EXPERIMENTAL SCIENCES, UNIVERSITY OF BRESCIA; DEPARTMENT OF CONTINUITY OF CARE AND FRAILTY, NEUROLOGY UNIT, ASST SPEDALI CIVILI OF BRESCIA, BRESCIA, ITALY – SPORT AND EXERCISE SCIENCE)
ELISABETTA FERRARI (NEMO-BRESCIA CLINICAL CENTER FOR NEUROMUSCULAR DISEASES, BRESCIA, ITALY – PSYCHOLOGY)
BEATRICE LABELLA (DEPARTMENT OF CLINICAL AND EXPERIMENTAL SCIENCES, UNIVERSITY OF BRESCIA; DEPARTMENT OF CONTINUITY OF CARE AND FRAILTY, NEUROLOGY UNIT, ASST SPEDALI CIVILI OF BRESCIA, BRESCIA, ITALY – NEUROLOGY)
CINZIA ZATTI (DEPARTMENT OF CLINICAL AND EXPERIMENTAL SCIENCES, UNIVERSITY OF BRESCIA; DEPARTMENT OF CONTINUITY OF CARE AND FRAILTY, NEUROLOGY UNIT, ASST SPEDALI CIVILI OF BRESCIA, BRESCIA, ITALY – NEUROLOGY)
CLINT HANSEN (DEPARTMENT OF NEUROLOGY, CHRISTIAN-ALBRECHTS-UNIVERSITY OF KIEL, KIEL, GERMANY – SPORT AND EXERCISE SCIENCE)
ROBBIN ROMIJNDERS (DEPARTMENT OF NEUROLOGY, CHRISTIAN-ALBRECHTS-UNIVERSITY OF KIEL, KIEL, GERMANY – BIOMEDICAL ENGINEERING)
FILOMENA CARIA (NEMO-BRESCIA CLINICAL CENTER FOR NEUROMUSCULAR DISEASES, BRESCIA, ITALY – NEUROLOGY)
SIMONA DAMIOLI (NEMO-BRESCIA CLINICAL CENTER FOR NEUROMUSCULAR DISEASES, BRESCIA, ITALY – PEDIATRIC NEUROLOGY)
ENRICA BERTELLA (NEMO-BRESCIA CLINICAL CENTER FOR NEUROMUSCULAR DISEASES, BRESCIA, ITALY – PNEUMOLOGY)
LORIS POLI (DEPARTMENT OF CONTINUITY OF CARE AND FRAILTY, NEUROLOGY UNIT, ASST SPEDALI CIVILI OF BRESCIA, BRESCIA, ITALY – NEUROLOGY)
LUCIA FERULLO (DEPARTMENT OF CLINICAL AND EXPERIMENTAL SCIENCES, UNIVERSITY OF BRESCIA; DEPARTMENT OF CONTINUITY OF CARE AND FRAILTY, NEUROLOGY UNIT, ASST SPEDALI CIVILI OF BRESCIA, BRESCIA, ITALY – NEUROLOGY)
EMANUELE OLIVIERI (DEPARTMENT OF CLINICAL AND EXPERIMENTAL SCIENCES, UNIVERSITY OF BRESCIA; DEPARTMENT OF CONTINUITY OF CARE AND FRAILTY, NEUROLOGY UNIT, ASST SPEDALI CIVILI OF BRESCIA, BRESCIA, ITALY – NEUROLOGY)
WALTER MAETZLER (DEPARTMENT OF NEUROLOGY, CHRISTIAN-ALBRECHTS-UNIVERSITY OF KIEL, KIEL, GERMANY – NEUROLOGY)
ALESSANDRO PADOVANI (DEPARTMENT OF CLINICAL AND EXPERIMENTAL SCIENCES, UNIVERSITY OF BRESCIA; DEPARTMENT OF CONTINUITY OF CARE AND FRAILTY, NEUROLOGY UNIT, ASST SPEDALI CIVILI OF BRESCIA, BRESCIA, ITALY – NEUROLOGY)
MASSIMILIANO FILOSTO (NEMO-BRESCIA CLINICAL CENTER FOR NEUROMUSCULAR DISEASES, BRESCIA, ITALY; DEPARTMENT OF CLINICAL AND EXPERIMENTAL SCIENCES, UNIVERSITY OF BRESCIA, ITALY – NEUROLOGY)

Presentatore

BARBARA RISI

Modalità

Oral Communication

Abstract

“Background: Myotonic Dystrophy type 1 (DM1) patients often present with cognitive impairment and gait abnormalities, such as increased gait variability, mostly related to distal muscle weakness. Since an influence of cognitive function on mobility is suggested in several neurological conditions, our aim was to evaluate gait parameters using mobile health technology (MHT) and their relationship with cognition in DM1.
Patients and Methods: Eight DM1 patients (49 yrs) and twenty healthy controls (57 yrs) underwent MHT-based gait analysis (Rehagait) during the six-minute walking test [6MWT] and a one-minute dual-task walking (“”check boxes”” [CB] and “”serial subtraction”” [SS]). The dual-task cost was calculated for each parameter. Data were compared using an adjusted ANCOVA. Patients underwent an extended neuropsychological battery.
Results: During 6MWT, DM1 patients showed greater double limb support variability (p = 0.005), step time variability (p = 0.005), and number of steps (p<0.001) than HC.
Looking at the three different tasks, DM1 patients took longer steps on the 6MWT than on the CB-1MWT (p = 0.030, 0.64 vs. 0.58 mt).
In the DM1 cohort, MoCA scores correlated negatively with the number of steps in the 6MWT (r = -0.997, p = 0.003). MoCA scores and Clock’s drawing correlated negatively with dual-task cost related to step length variability in both CB- and SS-1MWT.
Conclusion: DM1 patients showed greater variability and number of steps in regular walking compared to HC. Our findings suggest that cognitive performance, namely poorer visuo-constructive skills, might contribute to the observed gait abnormalities in DM1 and deserve to be validated in larger studies.”