Salvatore Rossi
Low ischemic stroke prevalence despite high burden of cardiovascular risk factors in Myotonic Distrophy type 1 (DM1): data from a retrospective, observational cohort study
Autori
- SALVATORE ROSSI (DEPARTMENT OF NEUROSCIENCE, UNIVERSITÀ CATTOLICA DEL SACRO CUORE-SEDE DI ROMA, LARGO F. VITO 1, 00168 ROME; FONDAZIONE UILDM LAZIO ONLUS, VIA P. SANTACROCE, 5 – 00167 ROMA – NEUROLOGIA)
- ANTONIO FUNCIS (DEPARTMENT OF NEUROSCIENCE, UNIVERSITÀ CATTOLICA DEL SACRO CUORE-SEDE DI ROMA, LARGO F. VITO 1, 00168 ROME, ITALY. – NEUROLOGIA)
- GIANMARCO DALLA ZANNA (DEPARTMENT OF NEUROSCIENCE, UNIVERSITÀ CATTOLICA DEL SACRO CUORE-SEDE DI ROMA, LARGO F. VITO 1, 00168 ROME, ITALY. – NEUROLOGIA)
- AURELIA ZAULI (NEUROLOGY UNIT, FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS, LARGO A. GEMELLI 8, 00168 ROME – NEUROLOGIA)
- CRISTINA SANCRICCA (NEUROLOGY UNIT, FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS, LARGO A. GEMELLI 8, 00168 ROME; FONDAZIONE UILDM LAZIO ONLUS, VIA P. SANTACROCE, 5 – 00167 ROMA – NEUROLOGIA)
- PIETRO CALIANDRO (DEPARTMENT OF NEUROSCIENCE, UNIVERSITÀ CATTOLICA DEL SACRO CUORE-SEDE DI ROMA, LARGO F. VITO 1, 00168 ROME; NEUROLOGY UNIT, FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS, LARGO A. GEMELLI 8, 00168 ROME – NEUROLOGIA)
- GABRIELLA SILVESTRI (DEPARTMENT OF NEUROSCIENCE, UNIVERSITÀ CATTOLICA DEL SACRO CUORE-SEDE DI ROMA, LARGO F. VITO 1, 00168 ROME; NEUROLOGY UNIT, FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS, LARGO A. GEMELLI 8, 00168 ROME – NEUROLOGIA)
Presentatore
SALVATORE ROSSI (DEPARTMENT OF NEUROSCIENCE, UNIVERSITÀ CATTOLICA DEL SACRO CUORE-SEDE DI ROMA, LARGO F. VITO 1, 00168 ROME; FONDAZIONE UILDM LAZIO ONLUS, VIA P. SANTACROCE, 5 – 00167 ROMA)
Modalità
Poster Session
Abstract
DM1 is a multisystem disease characterized by high prevalence of type II diabetes, dyslipidemia, atrial fibrillation (AF), obesity and OSAS, all common cardiovascular risk factors (CRF)s. Such CRFs, often in association, are expected to increase the risk of ischemic stroke (IS).
We retrospectively reviewed medical charts of 174 DM1 patients (47.7% males) aged>40 years (mean age at last evaluation 56 years), recording history of IS and all available CRFs, including total and LDL cholesterol, smoking habit, systemic arterial hypertension (SAH), diabetes mellitus, structural cardiomyopathy (systolic ejection fraction<50%), AF, obesity (Body Mass Index >30), obstructive sleep apnea syndrome (OSAS) and/or restrictive syndrome requiring non-invasive ventilation (NIV).
Total and LDL cholesterol were elevated in 59% and 44.4% of DM1 patients, respectively. 16.8% were smokers, 23.4% had SAH, 17.8% diabetes. 21.8% were obese, 10.6% had cardiomyopathy, 18.2% AF. 67,7% DM1 patients had NIV indication, but only 47.1% of them were NIV compliant.
Remarkably, 41.37% DM1 patients had 2 or more concomitant CRFs for IS. However, IS occurred only in 1 patient (0.6%), a 50 year-old female with 5 CFRs who had a large-vessel IS.
In developed countries, IS prevalence is about 3% in adults > 20 years. However, in our cohort, its prevalence resulted significantly lower despite high frequency of CRFs. These findings should prompt research to tailor preventive IS measures specific for DM1 (e.g., anticoagulants in patients at high risk of falls), and to identify any DM1-related “protective” factors possibly representing novel therapeutic targets for IS prevention in the general population.