Silvia FALSO
Seasonal Variation in Myasthenia Gravis Incidence
Autori
- SILVIA FALSO (1DEPARTMENT OF NEUROSCIENCE, CATHOLIC UNIVERSITY OF THE SACRED HEART; ROME, ITALY – NEUROLOGIA)
- PIETRO ZARA (2NEUROLOGY UNIT, UNIVERSITY HOSPITAL OF SASSARI; SASSARI, ITALY – NEUROLOGIA)
- SOFIA MARINI (1DEPARTMENT OF NEUROSCIENCE, CATHOLIC UNIVERSITY OF THE SACRED HEART; ROME, ITALY – NEUROLOGIA)
- MARIANGELA PUCI (3CLINICAL EPIDEMIOLOGY AND MEDICAL STATISTICS UNIT, UNIVERSITY HOSPITAL OF SASSARI; SASSARI, ITALY – STATISTICA MEDICA)
- ELEONORA SABATELLI (4NEUROLOGY UNIT, FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS; ROME, ITALY – NEUROLOGIA)
- GIOVANNI SOTGIU (3CLINICAL EPIDEMIOLOGY AND MEDICAL STATISTICS UNIT, UNIVERSITY HOSPITAL OF SASSARI; SASSARI, ITALY – STATISTICA MEDICA)
- MARTINA MARINI (1DEPARTMENT OF NEUROSCIENCE, CATHOLIC UNIVERSITY OF THE SACRED HEART; ROME, ITALY – NEUROLOGIA)
- GREGORIO SPAGNI (5GERMAN CENTER FOR NEURODEGENERATIVE DISEASES (DZNE) BERLIN; BERLIN, GERMANY – NEUROLOGIA)
- AMELIA EVOLI (1DEPARTMENT OF NEUROSCIENCE, CATHOLIC UNIVERSITY OF THE SACRED HEART; ROME, ITALY – NEUROLOGIA)
- PAOLO SOLLA (2NEUROLOGY UNIT, UNIVERSITY HOSPITAL OF SASSARI; SASSARI, ITALY – NEUROLOGIA)
- RAFFAELE IORIO (4NEUROLOGY UNIT, FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS; ROME, ITALY – NEUROLOGIA)
- ELIA SECHI (2NEUROLOGY UNIT, UNIVERSITY HOSPITAL OF SASSARI; SASSARI, ITALY – NEUROLOGIA)
Presentatore
SILVIA FALSO
Modalità
Poster Session
Abstract
“Background: Environmental factors may contribute to myasthenia gravis (MG) development, sometimes with seasonal patterns of exposure. However, whether seasonality has an impact on MG incidence remains unclear. We aimed to investigate the association between seasonality and MG onset.
Methods: We reviewed data of MG patients with acetylcholine receptor (AChR)-IgG and disease onset between January 2010-December 2019, from two Italian cohorts: 1) an hospital-based cohort and 2) a population-based cohort. MG cases were assigned to four season-trimesters based on month of onset to determine seasonal association with MG incidence. Results: We enrolled 316 patients:214 in the hospital-based and 102 in the population-based cohort. Median age at onset was 66 years (range, 8-92); Female accounted for 41%. The median number of new MG cases per season-trimester was significantly different, with the highest incidence in summer (June-August); p=0.009. The association between MG onset and summer months was still evident after stratification by cohort (hospital-based vs population-based), and was more evident (although not significant) in late-onset MG (age ≥50 years). Conclusion: MG onset may have a seasonal pattern with a peak in the summer months. Identifying the determinants of this association may improve our understanding of disease pathophysiology.”