Emanuela AGAZZI
SUBACUTE ATAXIC SENSITIVE SYNDROME
Autori
- EMANUELA AGAZZI (HPG23 – NEUROLOGIA)
- MANLIO SGARZI (HPG23 – NEUROLOGIA)
- GIORGIA CAMERA (HPG23 – NEUROLOGIA)
- PAOLO PAONE (HPG23 – NEUROLOGIA)
- DARIO ALIMONTI (HPG23 – NEUROLOGIA)
Presentatore
EMANUELA AGAZZI HPG23
Modalità
Poster Session
Abstract
“A 50 years old female received SARS-COV2 Pfeizer vaccine two weeks before presenting to our Emergency Unit reporting mild weakness in the lower limbs with two episodes of falling to the ground and progressive difficulty walking, with tingling paresthesias in her right arm, distal legs and feet.
Objectively, there was an absence of tendon reflexes slight weakness of the proximal muscles of the lower limbs with discrepancy at the TG test, distal legs hypopallestesia, widened base standing position , slightly ataxic gate. In medical history were repoted:epilepsy with parietal parasagittal meningioma, former opioid drug addiction, Hepatitis C treated in the past with interferon, seldom dizziness. The elettroneurography showed four limbs sensory axonal polyneuropathy, also of radial nerve. Four limbs motor evoked potentials were normal while somatosensory evoked potentials were absent due to severe peripheral suffering. Cerebrospinal fluid was normal, including viral test; blood test for autoimmunity, HIV, HTLV, Anti Borrelia Ig G and IgM Abs were negative. HCVAbs positive, with undetectable HCVRNA; onconeuronal antigene and anti ganglioside were negative. No evidence of vitamin or foline deficiency.PET SCAN was negative as brain and lumbar-sacral MRI.A toxic genesis was excluded .
During the three years follow up , she showed a slowly progressive sensory ataxya and more severe clinically upper limbs sensory impairment and more pronounced dizziness.
SCA genetic investigation for SCA 1-2-3-6-7-15-16-17 were negative.
Eletroneurography follow up was stable showing only axonal sensory polyneuropathy
Differential clinical diagnosis among sensory neuropathy, ganglionopathy, genetic clinical syndromes ( CANVAS?)”