Rossella D’Alessandro
Wearable technologies for the biomechanical analysis of motor disfunctions in DMD patients.
Autori
- ROSSELLA D’ALESSANDRO (DEPARTMENT OF PUBLIC HEALTH AND PEDIATRIC SCIENCES, SECTION OF CHILD AND ADOLESCENT NEUROPSYCHIATRY, UNIVERSITY OF TURIN, 10126, TURIN, ITALY – NEUROPSICHIATRIA INFANTILE)
- ELISA PANERO (DEPARTMENT OF PUBLIC HEALTH AND PEDIATRIC SCIENCES, SECTION OF CHILD AND ADOLESCENT NEUROPSYCHIATRY, UNIVERSITY OF TURIN, 10126, TURIN, ITALY – INGEGNERIA BIOMEDICA)
- ILARIA CAVALLINA (DEPARTMENT OF PUBLIC HEALTH AND PEDIATRIC SCIENCES, SECTION OF CHILD AND ADOLESCENT NEUROPSYCHIATRY, UNIVERSITY OF TURIN, 10126, TURIN, ITALY – TERAPISTA DELLA NEUROPSICOMOTRICITA’ DELL’ETA’ EVOLUTIVA)
- ENRICA ROLLE (DEPARTMENT OF PUBLIC HEALTH AND PEDIATRIC SCIENCES, SECTION OF CHILD AND ADOLESCENT NEUROPSYCHIATRY, UNIVERSITY OF TURIN, 10126, TURIN, ITALY – TERAPISTA DELLA NEUROPSICOMOTRICITA’ DELL’ETA’ EVOLUTIVA)
- FRANCESCA ROSSI (DEPARTMENT OF PUBLIC HEALTH AND PEDIATRIC SCIENCES, SECTION OF CHILD AND ADOLESCENT NEUROPSYCHIATRY, UNIVERSITY OF TURIN, 10126, TURIN, ITALY – TERAPISTA DELLA NEUROPSICOMOTRICITA’ DELL’ETA’ EVOLUTIVA)
- FRANCESCA RE (DEPARTMENT OF PUBLIC HEALTH AND PEDIATRIC SCIENCES, SECTION OF CHILD AND ADOLESCENT NEUROPSYCHIATRY, UNIVERSITY OF TURIN, 10126, TURIN, ITALY – MEDICO IN FORMAZIONE SPECIALISTICA IN NEUROPSICHIATRIA INFANTILE)
- FRANCESCA SERTORI (DEPARTMENT OF PUBLIC HEALTH AND PEDIATRIC SCIENCES, SECTION OF CHILD AND ADOLESCENT NEUROPSYCHIATRY, UNIVERSITY OF TURIN, 10126, TURIN, ITALY – MEDICO IN FORMAZIONE SPECIALISTICA IN NEUROPSICHIATRIA INFANTILE)
- LAURA GASTALDI (DEPARTMENT OF MECHANICAL AND AEROSPACE ENGINEERING, POLITECNICO DI TORINO, 10129, TURIN, ITALY; – INGEGNERIA MECCANICA)
- TIZIANA MONGINI (DEPARTMENT OF DEPARTMENT OF NEUROSCIENCES RLM, NEUROMUSCULAR UNIT, UNIVERSITY OF TURIN – NEUROLOGIA)
- FEDERICA RICCI (DEPARTMENT OF PUBLIC HEALTH AND PEDIATRIC SCIENCES, SECTION OF CHILD AND ADOLESCENT NEUROPSYCHIATRY, UNIVERSITY OF TURIN, 10126, TURIN, ITALY – NEUROPSICHIATRIA INFANTILE)
Presentatore
ROSSELLA D’ALESSANDRO
Modalità
Poster Session
Abstract
Children with Duchenne muscular dystrophy (DMD) adopt biomechanical compensations during movement to overcome strength loss and progressive reduction of joint range of motion. The disease progression causes temporal and spatial changes during locomotion. Wearable inertial technology (IMUs) has been proposed as a portable and easy-to-use solution for the instrumental monitoring of human movement, and the European Medicines Agency has recently qualified the 95th centile stride velocity assessed with wearable device as primary trial outcome measure. The aims of the current study are: i) to investigate the relation between clinical scores of 6-minute walk test (6MWT) and North Star Ambulatory Scale (NSAA), and instrumental parameters, ii) to evaluate the dynamic changes during prolonged walking. Ten ambulant DMD patients (mean age 10±2.5 years, mean height 125±6.8 cm, mean weight 30±8.2 kg) were enrolled. 3 IMUs (APDM OPAL, 200 Hz sample frequency) were positioned on the pelvis and shanks. Gait events were identified from 3D accelerations and angular velocities signals, then spatio-temporal parameters (i.e. cadence, average speed, stance and swing duration, harmonic ratio) were estimated. Results highlighted moderate-strong positive correlations of average speed, cadence, single support and vertical harmonic ratio with 6MWT and NSAA, while temporal parameters showed moderate-strong negative correlations. Some patients presented a variation of gait parameters and an increase of stride variability during the six-minute walking, possibly related to fatigue. IMU gait analysis could support the clinical assessment of walking impairments and walking-related fatigue. A longitudinal monitoring might be useful for the identification of significant outcomes for the pathology progression.